Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome
Identifieur interne : 000447 ( Main/Exploration ); précédent : 000446; suivant : 000448Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome
Auteurs : Basem M. Alraddadi ; Ismael Qushmaq ; Fahad M. Al-Hameed ; Yasser Mandourah ; Ghaleb A. Almekhlafi ; Jesna Jose ; Awad Al-Omari ; Ayman Kharaba ; Abdullah Almotairi ; Kasim Al Khatib ; Sarah Shalhoub ; Ahmed Abdulmomen ; Ahmed Mady ; Othman Solaiman ; Abdulsalam M. Al-Aithan ; Rajaa Al-Raddadi ; Ahmed Ragab ; Hanan H. Balkhy ; Abdulrahman Al Harthy ; Musharaf Sadat ; Haytham Tlayjeh ; Laura Merson ; Frederick G. Hayden ; Robert A. Fowler ; Yaseen M. ArabiSource :
- Influenza and Other Respiratory Viruses [ 1750-2640 ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
- Wicri :
- geographic : Arabie saoudite.
English descriptors
- KwdEn :
- MESH :
- geographic : Saudi Arabia.
- complications : Coronavirus Infections.
- statistics & numerical data : Noninvasive Ventilation.
- Aged, Critical Illness, Female, Humans, Intensive Care Units, Male, Middle Aged, Respiratory Distress Syndrome, Adult, Retrospective Studies, Treatment Failure, Treatment Outcome.
Abstract
Noninvasive ventilation (NIV) has been used in patients with the Middle East respiratory syndrome (MERS) with acute hypoxemic respiratory failure, but the effectiveness of this approach has not been studied.
Patients with MERS from 14 Saudi Arabian centers were included in this analysis. Patients who were initially managed with NIV were compared to patients who were managed only with invasive mechanical ventilation (invasive MV).
Of 302 MERS critically ill patients, NIV was used initially in 105 (35%) patients, whereas 197 (65%) patients were only managed with invasive MV. Patients who were managed with NIV initially had lower baseline SOFA score and less extensive infiltrates on chest radiograph compared with patients managed with invasive MV. The vast majority (92.4%) of patients who were managed initially with NIV required intubation and invasive mechanical ventilation, and were more likely to require inhaled nitric oxide compared to those who were managed initially with invasive MV. ICU and hospital length of stay were similar between NIV patients and invasive MV patients. The use of NIV was not independently associated with 90‐day mortality (propensity score‐adjusted odds ratio 0.61, 95% CI [0.23, 1.60]
In patients with MERS and acute hypoxemic respiratory failure, NIV failure was very high. The use of NIV was not associated with improved outcomes.
Url:
DOI: 10.1111/irv.12635
PubMed: 30884185
PubMed Central: 6586182
Affiliations:
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome</title>
<author><name sortKey="Alraddadi, Basem M" sort="Alraddadi, Basem M" uniqKey="Alraddadi B" first="Basem M." last="Alraddadi">Basem M. Alraddadi</name>
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<author><name sortKey="Al Ameed, Fahad M" sort="Al Ameed, Fahad M" uniqKey="Al Ameed F" first="Fahad M." last="Al-Hameed">Fahad M. Al-Hameed</name>
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<author><name sortKey="Almekhlafi, Ghaleb A" sort="Almekhlafi, Ghaleb A" uniqKey="Almekhlafi G" first="Ghaleb A." last="Almekhlafi">Ghaleb A. Almekhlafi</name>
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<author><name sortKey="Jose, Jesna" sort="Jose, Jesna" uniqKey="Jose J" first="Jesna" last="Jose">Jesna Jose</name>
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<author><name sortKey="Al Khatib, Kasim" sort="Al Khatib, Kasim" uniqKey="Al Khatib K" first="Kasim" last="Al Khatib">Kasim Al Khatib</name>
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<author><name sortKey="Shalhoub, Sarah" sort="Shalhoub, Sarah" uniqKey="Shalhoub S" first="Sarah" last="Shalhoub">Sarah Shalhoub</name>
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<author><name sortKey="Abdulmomen, Ahmed" sort="Abdulmomen, Ahmed" uniqKey="Abdulmomen A" first="Ahmed" last="Abdulmomen">Ahmed Abdulmomen</name>
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<author><name sortKey="Mady, Ahmed" sort="Mady, Ahmed" uniqKey="Mady A" first="Ahmed" last="Mady">Ahmed Mady</name>
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<author><name sortKey="Solaiman, Othman" sort="Solaiman, Othman" uniqKey="Solaiman O" first="Othman" last="Solaiman">Othman Solaiman</name>
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<author><name sortKey="Al Ithan, Abdulsalam M" sort="Al Ithan, Abdulsalam M" uniqKey="Al Ithan A" first="Abdulsalam M." last="Al-Aithan">Abdulsalam M. Al-Aithan</name>
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<author><name sortKey="Al Addadi, Rajaa" sort="Al Addadi, Rajaa" uniqKey="Al Addadi R" first="Rajaa" last="Al-Raddadi">Rajaa Al-Raddadi</name>
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<author><name sortKey="Ragab, Ahmed" sort="Ragab, Ahmed" uniqKey="Ragab A" first="Ahmed" last="Ragab">Ahmed Ragab</name>
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<author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name>
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<series><title level="j">Influenza and Other Respiratory Viruses</title>
<idno type="ISSN">1750-2640</idno>
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<term>Coronavirus Infections (complications)</term>
<term>Critical Illness</term>
<term>Female</term>
<term>Humans</term>
<term>Intensive Care Units</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Noninvasive Ventilation (statistics & numerical data)</term>
<term>Respiratory Distress Syndrome, Adult</term>
<term>Retrospective Studies</term>
<term>Saudi Arabia</term>
<term>Treatment Failure</term>
<term>Treatment Outcome</term>
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<term>Arabie saoudite</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à coronavirus ()</term>
<term>Maladie grave</term>
<term>Mâle</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Syndrome de détresse respiratoire de l'adulte</term>
<term>Unités de soins intensifs</term>
<term>Ventilation non effractive ()</term>
<term>Échec thérapeutique</term>
<term>Études rétrospectives</term>
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<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Saudi Arabia</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term>
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<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Noninvasive Ventilation</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Critical Illness</term>
<term>Female</term>
<term>Humans</term>
<term>Intensive Care Units</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Respiratory Distress Syndrome, Adult</term>
<term>Retrospective Studies</term>
<term>Treatment Failure</term>
<term>Treatment Outcome</term>
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<term>Arabie saoudite</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à coronavirus</term>
<term>Maladie grave</term>
<term>Mâle</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
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<term>Échec thérapeutique</term>
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<front><div type="abstract" xml:lang="en"><sec id="irv12635-sec-0001"><title>Background</title>
<p>Noninvasive ventilation (NIV) has been used in patients with the Middle East respiratory syndrome (MERS) with acute hypoxemic respiratory failure, but the effectiveness of this approach has not been studied.</p>
</sec>
<sec id="irv12635-sec-0002"><title>Methods</title>
<p>Patients with MERS from 14 Saudi Arabian centers were included in this analysis. Patients who were initially managed with NIV were compared to patients who were managed only with invasive mechanical ventilation (invasive MV).</p>
</sec>
<sec id="irv12635-sec-0003"><title>Results</title>
<p>Of 302 MERS critically ill patients, NIV was used initially in 105 (35%) patients, whereas 197 (65%) patients were only managed with invasive MV. Patients who were managed with NIV initially had lower baseline SOFA score and less extensive infiltrates on chest radiograph compared with patients managed with invasive MV. The vast majority (92.4%) of patients who were managed initially with NIV required intubation and invasive mechanical ventilation, and were more likely to require inhaled nitric oxide compared to those who were managed initially with invasive MV. ICU and hospital length of stay were similar between NIV patients and invasive MV patients. The use of NIV was not independently associated with 90‐day mortality (propensity score‐adjusted odds ratio 0.61, 95% CI [0.23, 1.60] <italic>P</italic>
= 0.27).</p>
</sec>
<sec id="irv12635-sec-0004"><title>Conclusions</title>
<p>In patients with MERS and acute hypoxemic respiratory failure, NIV failure was very high. The use of NIV was not associated with improved outcomes.</p>
</sec>
</div>
</front>
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</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Abdulmomen, Ahmed" sort="Abdulmomen, Ahmed" uniqKey="Abdulmomen A" first="Ahmed" last="Abdulmomen">Ahmed Abdulmomen</name>
<name sortKey="Al Addadi, Rajaa" sort="Al Addadi, Rajaa" uniqKey="Al Addadi R" first="Rajaa" last="Al-Raddadi">Rajaa Al-Raddadi</name>
<name sortKey="Al Ameed, Fahad M" sort="Al Ameed, Fahad M" uniqKey="Al Ameed F" first="Fahad M." last="Al-Hameed">Fahad M. Al-Hameed</name>
<name sortKey="Al Harthy, Abdulrahman" sort="Al Harthy, Abdulrahman" uniqKey="Al Harthy A" first="Abdulrahman" last="Al Harthy">Abdulrahman Al Harthy</name>
<name sortKey="Al Ithan, Abdulsalam M" sort="Al Ithan, Abdulsalam M" uniqKey="Al Ithan A" first="Abdulsalam M." last="Al-Aithan">Abdulsalam M. Al-Aithan</name>
<name sortKey="Al Khatib, Kasim" sort="Al Khatib, Kasim" uniqKey="Al Khatib K" first="Kasim" last="Al Khatib">Kasim Al Khatib</name>
<name sortKey="Al Mari, Awad" sort="Al Mari, Awad" uniqKey="Al Mari A" first="Awad" last="Al-Omari">Awad Al-Omari</name>
<name sortKey="Almekhlafi, Ghaleb A" sort="Almekhlafi, Ghaleb A" uniqKey="Almekhlafi G" first="Ghaleb A." last="Almekhlafi">Ghaleb A. Almekhlafi</name>
<name sortKey="Almotairi, Abdullah" sort="Almotairi, Abdullah" uniqKey="Almotairi A" first="Abdullah" last="Almotairi">Abdullah Almotairi</name>
<name sortKey="Alraddadi, Basem M" sort="Alraddadi, Basem M" uniqKey="Alraddadi B" first="Basem M." last="Alraddadi">Basem M. Alraddadi</name>
<name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M." last="Arabi">Yaseen M. Arabi</name>
<name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name>
<name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A." last="Fowler">Robert A. Fowler</name>
<name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G." last="Hayden">Frederick G. Hayden</name>
<name sortKey="Jose, Jesna" sort="Jose, Jesna" uniqKey="Jose J" first="Jesna" last="Jose">Jesna Jose</name>
<name sortKey="Kharaba, Ayman" sort="Kharaba, Ayman" uniqKey="Kharaba A" first="Ayman" last="Kharaba">Ayman Kharaba</name>
<name sortKey="Mady, Ahmed" sort="Mady, Ahmed" uniqKey="Mady A" first="Ahmed" last="Mady">Ahmed Mady</name>
<name sortKey="Mandourah, Yasser" sort="Mandourah, Yasser" uniqKey="Mandourah Y" first="Yasser" last="Mandourah">Yasser Mandourah</name>
<name sortKey="Merson, Laura" sort="Merson, Laura" uniqKey="Merson L" first="Laura" last="Merson">Laura Merson</name>
<name sortKey="Qushmaq, Ismael" sort="Qushmaq, Ismael" uniqKey="Qushmaq I" first="Ismael" last="Qushmaq">Ismael Qushmaq</name>
<name sortKey="Ragab, Ahmed" sort="Ragab, Ahmed" uniqKey="Ragab A" first="Ahmed" last="Ragab">Ahmed Ragab</name>
<name sortKey="Sadat, Musharaf" sort="Sadat, Musharaf" uniqKey="Sadat M" first="Musharaf" last="Sadat">Musharaf Sadat</name>
<name sortKey="Shalhoub, Sarah" sort="Shalhoub, Sarah" uniqKey="Shalhoub S" first="Sarah" last="Shalhoub">Sarah Shalhoub</name>
<name sortKey="Solaiman, Othman" sort="Solaiman, Othman" uniqKey="Solaiman O" first="Othman" last="Solaiman">Othman Solaiman</name>
<name sortKey="Tlayjeh, Haytham" sort="Tlayjeh, Haytham" uniqKey="Tlayjeh H" first="Haytham" last="Tlayjeh">Haytham Tlayjeh</name>
</noCountry>
</tree>
</affiliations>
</record>
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